Endocrine Abstracts

Introduction: Cinacalcet is a positive allosteric modulator of the calcium sensing receptor successfully used to decrease serum calcium in primary hyperparathyroidism (pHPT) patients in the short-term, but long-term data are scarce. In this single-centre retrospective analysis, we investigated the efficacy and safety of cinacalcet in pHPT patients who received more than 5 years of treatment.Methods: Statistical analysis was performed using free online so...

Aim: Differential diagnosis (DD) of thyrotoxicosis is critical as the treatment of the three main causes of this condition (Graves’ disease [GD], Toxic Multinodular Goitre [TMG], and Thyroiditis [TS]) differs substantially. Recently published diagnostic algorithms investigating hyperthyroidism embrace the presence of thyrotropin receptor (TSH-R) antibodies (TRab) as the first and most cruicial diagnostic step. Although TRab measurement has important limitations (some can ...

Aim: Bone turnover markers (BTMs) predict more rapid rates of bone loss. However, most of these studies have been carried out in postmenopausal women. Few prospective studies have examined the degradation marker C-terminal telopeptide of type I collagen (CTX) and the bone formation marker N-aminoterminal propeptide of type I collagen (P1NP) measured during the menopausal transition to predict the subsequent bone loss.Methods: We performed a prospective c...

Aim: Non-alcoholic fatty liver disease (NAFLD) and type 2 Diabetes (T2D) are common conditions that frequently co-exist. Studies have shown an increase likelihood of micro and macrovascular complications in this population, as well, as an increased risk of developing more severe forms of liver disease. The aim of this study was to identify diabetic complications in patients with both diseases and search for an association with liver stiffness assessed by Liver Elastography (LE...

Objectives and methods: The mechanism that explains the different weight response to various treatments in obese type 2 diabetes (DM2) patients, compared to those without diabetes, is still unknown. In order to establish the weight response to Roux-en-Y Gastric Bypass (RYGB), 268 patients with morbid obesity (IMC 45.4±0.4 kg/m2) were classified by OGTT as having normal glucose tolerance (Grupo A. n=107), prediabetes (Grupo B. n=96) an...

Aim: A key diagnostic step to determine the cause of hyperthyroidism is the measurement of circulating thyroid-stimulating immunoglobulin (TSI). High levels are associated with Graves’ disease (GD). A thyroid scintigraphy (TRS) is recommended when TSI is absent or its measurement unavailable, as TRS is capable of differentiating between GD (diffuse uptake) and toxic goitre (TG) (patchy uptake). Nevertheless, and while rarely necessary, histopathology remain the best metho...

Introduction: The role of external beam radiotherapy (EBRT) as primary or as adjuvant therapy in the non-undifferentiated thyroid cancer (NUTC) is controversial. Most published data refer to retrospective case series. Therefore, little is known about the correlation between tumor markers and radiologic measurements of tumor response.Objectives: The study aimed to analyze the kinetics of tumor markers and radiologic measurement of tumor response after EBR...

Patients with impaired glucose metabolism, either prediabetes (preD) or type 2 Diabetes (T2D), and non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular events. Recent studies have shown a relationship between epicardial fat and myocardial ischemia.Objective: To determine whether hepatic fibrosis assessed by liver elastography (LE) or Fibrosis-4 (FIB-4) score correlates with epicardial fat volume quantified by computed tomo...